Endocrine Abstracts

Objective: A great number of patients are self-referred to endocrinologist. Most of these patients had some research of their symptoms and have a specific diagnosis that they want to investigate.Methods: A retrospective chart review of 628 new consults conducted in one outpatient endocrine office at University of California, Los Angeles was conducted.Results: Of the 628 new patients 326 were referred by another physician and were e...

Background: Moderate hypophosphatemia is not an uncommon finding. As usually requiring no specific intervention, it might be neglected and serum phosphate measurements are sometimes skipped. Only 1% of phosphorus is in extracellular fluid so it is not a reliable marker of body phosphorus reserve and refractory chronic hypophosphatemia might be a sign of severe phosphorus depletion.Case presentation: A fifty-two-year-old male patient presented with a 12-m...

Previous studies suggest that individuals characterized by high trait hostility may be more sensitive to stress and that this may contribute to their greater vulnerability to alcohol abuse. To characterize the stress reactivity of hostile individuals and to evaluate the possibility that serotonergic dysfunction may underlie their susceptibility to stress, we examined the effects of acute dietary tryptophan enhancement and stress on mood and physiological reactivity in low (LoH...

The term polyglandular autoimmune syndrome (PAS) is used when there is a dysfunction of two or more endocrine glands associated with circulating antibodies directed at organspecific included glands. Neufeld and Blizzard classified PAS into two categories: type I and type II with the newly added category, type III, which does not include the adrenal cortex. PAS III includes several autoimmune diseases (autoimmune thyroiditis, immune-mediated diabetes mellitus, pernicious anemia...

Craniopharyngiomas are rare tumors that in a high percentage of patients leads to damage of periventricular nucleus and suprachiasmatic nucleus, what leads to the development of hypothalamic obesity. Hypotalamic obesity is associated with numerous metabolic disorders. Regardless of the numerous studies of new therapeutic approaches, there is still no official approved effective (phramacological or bariatric) treatment for hypotalamic obesity. Liraglutide is an GLP-1 analogue t...

B-pancreatic cells are programmed to react to plasma glucose level with insulin secretion. Insulin secretion is precisely regulated and in the physiological conditions fasting glucose levels are maintained in the range 3.5–5.5 mmol/l. In hyperinsulinemic hypoglycemia, a disorder of the regulation of insulin secretion, insulin secretion continues at low concentrations of plasma glucose. In adults hyperinsulinemic hypoglycemia is the cause of 0.5 to 5.0% of hypoglicaemias a...

The conversion of Hashimoto thyroiditis (HT) to hypothyroidism is frequently observed in daily clinical practice, but the development of Grave’s disease (GD) after long-standing hypothyroidism is rare and intriguing. A 70-year-old woman visited an endocrinologist, complaining of increased heart rate, anxiety, and a feeling of discomfort in the neck. Past medical history revealed HT with hypothyroidism. Laboratory tests showed significantly increased thyroid-stimulating ho...

Background: Sport results might be influenced by advances in sport science leading to better training, but also by new knowledge of human physiology and endocrinology. Doping and its detection as well as impact of regulations like testosterone limitations for women category eligibility might be reflected in top sport performances.Objectives: We aimed to retrospectively analyse factors influencing top performances in short, middle, and long-distance runni...

Background: Bone mineral density measurement sometimes reveals osteoporosis that is a consequence of undiagnosed or neglected long-standing health disorders. These secondary causes of osteoporosis should be carefully investigated, especially in men.Case Presentation: A 63-year-old male complained of back pain and was referred to endocrinology clinic due to a poor densitometry finding indicating osteoporosis. He presented with severe obesity (body mass in...

Introduction: It is a well-known fact that in Baltic Sea region there is low level of ecological selenium and iodine in soil and water, which can lead to subclinical hypo-activity of thyroid gland. By epidemiological data of that region, chronic stress and low insolation favour the decrease of metabolic rate, hypercholesterolemia and obesity in 30% of population.Method: In Dietological Centre of Jurmala, Latvia, 87 obese patients, in the age group of 25&...